Valacyclover Hydrochloric
Valacyclover Hydrochloric Brand names, Valacyclover Hydrochloric Analogs
Valacyclover Hydrochloric Brand Names Mixture
- No information avaliable
Valacyclover Hydrochloric Chemical_Formula
C13H20N6O4
Valacyclover Hydrochloric RX_link
http://www.rxlist.com/cgi/generic3/valacyclovir.htm
Valacyclover Hydrochloric fda sheet
Valacyclover Hydrochloric msds (material safety sheet)
Valacyclover Hydrochloric Synthesis Reference
No information avaliable
Valacyclover Hydrochloric Molecular Weight
324.336 g/mol
Valacyclover Hydrochloric Melting Point
No information avaliable
Valacyclover Hydrochloric H2O Solubility
No information avaliable
Valacyclover Hydrochloric State
Solid
Valacyclover Hydrochloric LogP
No information avaliable
Valacyclover Hydrochloric Dosage Forms
Tablet
Valacyclover Hydrochloric Indication
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Valacyclover Hydrochloric Pharmacology
Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.
Valacyclover Hydrochloric Absorption
After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.
Valacyclover Hydrochloric side effects and Toxicity
Adverse effects of overexposure might include headache and nausea.
Valacyclover Hydrochloric Patient Information
Valacyclover Hydrochloric Organisms Affected
Human herpes virus
