Valaciclovir Hydrochloride
Valaciclovir Hydrochloride Brand names, Valaciclovir Hydrochloride Analogs
Valaciclovir Hydrochloride Brand Names Mixture
- No information avaliable
Valaciclovir Hydrochloride Chemical_Formula
C13H20N6O4
Valaciclovir Hydrochloride RX_link
http://www.rxlist.com/cgi/generic3/valacyclovir.htm
Valaciclovir Hydrochloride fda sheet
Valaciclovir Hydrochloride msds (material safety sheet)
Valaciclovir Hydrochloride Synthesis Reference
No information avaliable
Valaciclovir Hydrochloride Molecular Weight
324.336 g/mol
Valaciclovir Hydrochloride Melting Point
No information avaliable
Valaciclovir Hydrochloride H2O Solubility
No information avaliable
Valaciclovir Hydrochloride State
Solid
Valaciclovir Hydrochloride LogP
No information avaliable
Valaciclovir Hydrochloride Dosage Forms
Tablet
Valaciclovir Hydrochloride Indication
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Valaciclovir Hydrochloride Pharmacology
Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.
Valaciclovir Hydrochloride Absorption
After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.
Valaciclovir Hydrochloride side effects and Toxicity
Adverse effects of overexposure might include headache and nausea.
Valaciclovir Hydrochloride Patient Information
Valaciclovir Hydrochloride Organisms Affected
Human herpes virus
