PharmacyCodes



Valaciclovir Hcl en es it fr

Valaciclovir Hcl Brand names, Valaciclovir Hcl Analogs

Valaciclovir Hcl Brand Names Mixture

  • No information avaliable

Valaciclovir Hcl Chemical_Formula

C13H20N6O4

Valaciclovir Hcl RX_link

http://www.rxlist.com/cgi/generic3/valacyclovir.htm

Valaciclovir Hcl fda sheet

Valaciclovir_Hcl FDA

Valaciclovir Hcl msds (material safety sheet)

Valaciclovir_Hcl MSDS

Valaciclovir Hcl Synthesis Reference

No information avaliable

Valaciclovir Hcl Molecular Weight

324.336 g/mol

Valaciclovir Hcl Melting Point

No information avaliable

Valaciclovir Hcl H2O Solubility

No information avaliable

Valaciclovir Hcl State

Solid

Valaciclovir Hcl LogP

No information avaliable

Valaciclovir Hcl Dosage Forms

Tablet

Valaciclovir Hcl Indication

For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.

Valaciclovir Hcl Pharmacology

Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.

Valaciclovir Hcl Absorption

After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.

Valaciclovir Hcl side effects and Toxicity

Adverse effects of overexposure might include headache and nausea.

Valaciclovir Hcl Patient Information

Valaciclovir Hcl Organisms Affected

Human herpes virus