Valaciclovir
Valaciclovir Brand names, Valaciclovir Analogs
Valaciclovir Brand Names Mixture
- No information avaliable
Valaciclovir Chemical_Formula
C13H20N6O4
Valaciclovir RX_link
http://www.rxlist.com/cgi/generic3/valacyclovir.htm
Valaciclovir fda sheet
Valaciclovir msds (material safety sheet)
Valaciclovir Synthesis Reference
No information avaliable
Valaciclovir Molecular Weight
324.336 g/mol
Valaciclovir Melting Point
No information avaliable
Valaciclovir H2O Solubility
No information avaliable
Valaciclovir State
Solid
Valaciclovir LogP
No information avaliable
Valaciclovir Dosage Forms
Tablet
Valaciclovir Indication
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Valaciclovir Pharmacology
Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.
Valaciclovir Absorption
After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.
Valaciclovir side effects and Toxicity
Adverse effects of overexposure might include headache and nausea.
Valaciclovir Patient Information
Valaciclovir Organisms Affected
Human herpes virus
