Valacyclovir Hydrochloride
Valacyclovir Hydrochloride Brand names, Valacyclovir Hydrochloride Analogs
Valacyclovir Hydrochloride Brand Names Mixture
- No information avaliable
Valacyclovir Hydrochloride Chemical_Formula
C13H20N6O4
Valacyclovir Hydrochloride RX_link
http://www.rxlist.com/cgi/generic3/valacyclovir.htm
Valacyclovir Hydrochloride fda sheet
Valacyclovir Hydrochloride msds (material safety sheet)
Valacyclovir Hydrochloride Synthesis Reference
No information avaliable
Valacyclovir Hydrochloride Molecular Weight
324.336 g/mol
Valacyclovir Hydrochloride Melting Point
No information avaliable
Valacyclovir Hydrochloride H2O Solubility
No information avaliable
Valacyclovir Hydrochloride State
Solid
Valacyclovir Hydrochloride LogP
No information avaliable
Valacyclovir Hydrochloride Dosage Forms
Tablet
Valacyclovir Hydrochloride Indication
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Valacyclovir Hydrochloride Pharmacology
Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.
Valacyclovir Hydrochloride Absorption
After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.
Valacyclovir Hydrochloride side effects and Toxicity
Adverse effects of overexposure might include headache and nausea.
Valacyclovir Hydrochloride Patient Information
Valacyclovir Hydrochloride Organisms Affected
Human herpes virus
