Urocortisone

Urocortisone Brand names, Urocortisone Analogs

Urocortisone Brand Names Mixture

No information avaliable

Urocortisone Chemical_Formula

C₂₁H₃₀O₅

Urocortisone RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Urocortisone fda sheet

Urocortisone FDA

Urocortisone msds (material safety sheet)

Urocortisone MSDS

Urocortisone Synthesis Reference

No information avaliable

Urocortisone Molecular Weight

362.46 g/mol

Urocortisone Melting Point

220 ^oC

Urocortisone H₂O Solubility

320 mg/L

Urocortisone State

Solid

Urocortisone LogP

1.692

Urocortisone Dosage Forms

Cream; Ointment; Enemas

Urocortisone Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Urocortisone Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Urocortisone Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Urocortisone side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Urocortisone Patient Information