Remederm HC

Remederm HC Brand names, Remederm HC Analogs

Remederm HC Brand Names Mixture

No information avaliable

Remederm HC Chemical_Formula

C₂₁H₃₀O₅

Remederm HC RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Remederm HC fda sheet

Remederm_HC FDA

Remederm HC msds (material safety sheet)

Remederm_HC MSDS

Remederm HC Synthesis Reference

No information avaliable

Remederm HC Molecular Weight

362.46 g/mol

Remederm HC Melting Point

220 ^oC

Remederm HC H₂O Solubility

320 mg/L

Remederm HC State

Solid

Remederm HC LogP

1.692

Remederm HC Dosage Forms

Cream; Ointment; Enemas

Remederm HC Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Remederm HC Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Remederm HC Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Remederm HC side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Remederm HC Patient Information