Domolene-HC

Domolene-HC Brand names, Domolene-HC Analogs

Domolene-HC Brand Names Mixture

No information avaliable

Domolene-HC Chemical_Formula

C₂₁H₃₀O₅

Domolene-HC RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Domolene-HC fda sheet

Domolene-HC FDA

Domolene-HC msds (material safety sheet)

Domolene-HC MSDS

Domolene-HC Synthesis Reference

No information avaliable

Domolene-HC Molecular Weight

362.46 g/mol

Domolene-HC Melting Point

220 ^oC

Domolene-HC H₂O Solubility

320 mg/L

Domolene-HC State

Solid

Domolene-HC LogP

1.692

Domolene-HC Dosage Forms

Cream; Ointment; Enemas

Domolene-HC Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Domolene-HC Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Domolene-HC Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Domolene-HC side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Domolene-HC Patient Information