Hydrocortone

Hydrocortone Brand names, Hydrocortone Analogs

Hydrocortone Brand Names Mixture

No information avaliable

Hydrocortone Chemical_Formula

C₂₁H₃₀O₅

Hydrocortone RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Hydrocortone fda sheet

Hydrocortone FDA

Hydrocortone msds (material safety sheet)

Hydrocortone MSDS

Hydrocortone Synthesis Reference

No information avaliable

Hydrocortone Molecular Weight

362.46 g/mol

Hydrocortone Melting Point

220 ^oC

Hydrocortone H₂O Solubility

320 mg/L

Hydrocortone State

Solid

Hydrocortone LogP

1.692

Hydrocortone Dosage Forms

Cream; Ointment; Enemas

Hydrocortone Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Hydrocortone Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Hydrocortone Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Hydrocortone side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortone Patient Information