Sigmacort

Sigmacort Brand names, Sigmacort Analogs

Sigmacort Brand Names Mixture

No information avaliable

Sigmacort Chemical_Formula

C₂₁H₃₀O₅

Sigmacort RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Sigmacort fda sheet

Sigmacort FDA

Sigmacort msds (material safety sheet)

Sigmacort MSDS

Sigmacort Synthesis Reference

No information avaliable

Sigmacort Molecular Weight

362.46 g/mol

Sigmacort Melting Point

220 ^oC

Sigmacort H₂O Solubility

320 mg/L

Sigmacort State

Solid

Sigmacort LogP

1.692

Sigmacort Dosage Forms

Cream; Ointment; Enemas

Sigmacort Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Sigmacort Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Sigmacort Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Sigmacort side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Sigmacort Patient Information