Hydrocortisone Valerate

Hydrocortisone Valerate Brand names, Hydrocortisone Valerate Analogs

Hydrocortisone Valerate Brand Names Mixture

No information avaliable

Hydrocortisone Valerate Chemical_Formula

C₂₁H₃₀O₅

Hydrocortisone Valerate RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Hydrocortisone Valerate fda sheet

Hydrocortisone_Valerate FDA

Hydrocortisone Valerate msds (material safety sheet)

Hydrocortisone_Valerate MSDS

Hydrocortisone Valerate Synthesis Reference

No information avaliable

Hydrocortisone Valerate Molecular Weight

362.46 g/mol

Hydrocortisone Valerate Melting Point

220 ^oC

Hydrocortisone Valerate H₂O Solubility

320 mg/L

Hydrocortisone Valerate State

Solid

Hydrocortisone Valerate LogP

1.692

Hydrocortisone Valerate Dosage Forms

Cream; Ointment; Enemas

Hydrocortisone Valerate Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Hydrocortisone Valerate Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Hydrocortisone Valerate Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Hydrocortisone Valerate side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortisone Valerate Patient Information