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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H14ClN3O4S3
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
431.94 g/mol
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Melting Point
231.5 oC
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H2O Solubility
8.91 mg/L
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State
Solid
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LogP
2.918
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Dosage Forms
Tablet
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Indication
For the treatment of high blood pressure and management of edema.
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Pharmacology
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
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Absorption
Absorbed in the digestive tract.
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side effects and Toxicity
Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
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Patient Information
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Organisms Affected
Humans and other mammals