Proaqua
Brand names,
Proaqua
Analogs
Proaqua
Brand Names Mixture
Proaqua
Chemical_Formula
C15H14ClN3O4S3
Proaqua
RX_link
No information avaliable
Proaqua
fda sheet
Proaqua
msds (material safety sheet)
Proaqua
Synthesis Reference
No information avaliable
Proaqua
Molecular Weight
431.94 g/mol
Proaqua
Melting Point
231.5 oC
Proaqua
H2O Solubility
8.91 mg/L
Proaqua
State
Solid
Proaqua
LogP
2.918
Proaqua
Dosage Forms
Tablet
Proaqua
Indication
For the treatment of high blood pressure and management of edema.
Proaqua
Pharmacology
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Proaqua
Absorption
Absorbed in the digestive tract.
Proaqua
side effects and Toxicity
Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
Proaqua
Patient Information
Proaqua
Organisms Affected
Humans and other mammals