Diucen
Brand names,
Diucen
Analogs
Diucen
Brand Names Mixture
Diucen
Chemical_Formula
C15H14ClN3O4S3
Diucen
RX_link
No information avaliable
Diucen
fda sheet
Diucen
msds (material safety sheet)
Diucen
Synthesis Reference
No information avaliable
Diucen
Molecular Weight
431.94 g/mol
Diucen
Melting Point
231.5 oC
Diucen
H2O Solubility
8.91 mg/L
Diucen
State
Solid
Diucen
LogP
2.918
Diucen
Dosage Forms
Tablet
Diucen
Indication
For the treatment of high blood pressure and management of edema.
Diucen
Pharmacology
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Diucen
Absorption
Absorbed in the digestive tract.
Diucen
side effects and Toxicity
Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
Diucen
Patient Information
Diucen
Organisms Affected
Humans and other mammals