Triapten
Triapten Brand names, Triapten Analogs
Triapten Brand Names Mixture
- No information avaliable
Triapten Chemical_Formula
CH3O5P
Triapten RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Triapten fda sheet
Triapten msds (material safety sheet)
Triapten Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Triapten Molecular Weight
126.005 g/mol
Triapten Melting Point
88.06 oC
Triapten H2O Solubility
Complete
Triapten State
Solid
Triapten LogP
No information avaliable
Triapten Dosage Forms
Injection
Triapten Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Triapten Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Triapten Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Triapten side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Triapten Patient Information
Triapten Organisms Affected
Human herpes viruses
