Phgosphonocarboxylic acid
Phgosphonocarboxylic acid Brand names, Phgosphonocarboxylic acid Analogs
Phgosphonocarboxylic acid Brand Names Mixture
- No information avaliable
Phgosphonocarboxylic acid Chemical_Formula
CH3O5P
Phgosphonocarboxylic acid RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Phgosphonocarboxylic acid fda sheet
Phgosphonocarboxylic acid msds (material safety sheet)
Phgosphonocarboxylic acid Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Phgosphonocarboxylic acid Molecular Weight
126.005 g/mol
Phgosphonocarboxylic acid Melting Point
88.06 oC
Phgosphonocarboxylic acid H2O Solubility
Complete
Phgosphonocarboxylic acid State
Solid
Phgosphonocarboxylic acid LogP
No information avaliable
Phgosphonocarboxylic acid Dosage Forms
Injection
Phgosphonocarboxylic acid Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Phgosphonocarboxylic acid Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Phgosphonocarboxylic acid Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Phgosphonocarboxylic acid side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Phgosphonocarboxylic acid Patient Information
Phgosphonocarboxylic acid Organisms Affected
Human herpes viruses
