Forscarnet sodium
Forscarnet sodium Brand names, Forscarnet sodium Analogs
Forscarnet sodium Brand Names Mixture
- No information avaliable
Forscarnet sodium Chemical_Formula
CH3O5P
Forscarnet sodium RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Forscarnet sodium fda sheet
Forscarnet sodium msds (material safety sheet)
Forscarnet sodium Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Forscarnet sodium Molecular Weight
126.005 g/mol
Forscarnet sodium Melting Point
88.06 oC
Forscarnet sodium H2O Solubility
Complete
Forscarnet sodium State
Solid
Forscarnet sodium LogP
No information avaliable
Forscarnet sodium Dosage Forms
Injection
Forscarnet sodium Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Forscarnet sodium Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Forscarnet sodium Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Forscarnet sodium side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Forscarnet sodium Patient Information
Forscarnet sodium Organisms Affected
Human herpes viruses
