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PFA Brand names, PFA Analogs

PFA Brand Names Mixture

  • No information avaliable

PFA Chemical_Formula


PFA RX_link

PFA fda sheet

PFA msds (material safety sheet)


PFA Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

PFA Molecular Weight

126.005 g/mol

PFA Melting Point

88.06 oC

PFA H2O Solubility


PFA State



No information avaliable

PFA Dosage Forms


PFA Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

PFA Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

PFA Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

PFA side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

PFA Patient Information

PFA Organisms Affected

Human herpes viruses