PFA
PFA Brand names, PFA Analogs
PFA Brand Names Mixture
- No information avaliable
PFA Chemical_Formula
CH3O5P
PFA RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
PFA fda sheet
PFA msds (material safety sheet)
PFA Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
PFA Molecular Weight
126.005 g/mol
PFA Melting Point
88.06 oC
PFA H2O Solubility
Complete
PFA State
Solid
PFA LogP
No information avaliable
PFA Dosage Forms
Injection
PFA Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
PFA Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
PFA Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
PFA side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
PFA Patient Information
PFA Organisms Affected
Human herpes viruses
