Carboxyphosphonic acid en es it fr

Carboxyphosphonic acid Brand names, Carboxyphosphonic acid Analogs

Carboxyphosphonic acid Brand Names Mixture

  • No information avaliable

Carboxyphosphonic acid Chemical_Formula

CH3O5P

Carboxyphosphonic acid RX_link

http://www.rxlist.com/cgi/generic2/foscarnet.htm

Carboxyphosphonic acid fda sheet

Carboxyphosphonic acid msds (material safety sheet)

Carboxyphosphonic_acid MSDS

Carboxyphosphonic acid Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

Carboxyphosphonic acid Molecular Weight

126.005 g/mol

Carboxyphosphonic acid Melting Point

88.06 oC

Carboxyphosphonic acid H2O Solubility

Complete

Carboxyphosphonic acid State

Solid

Carboxyphosphonic acid LogP

No information avaliable

Carboxyphosphonic acid Dosage Forms

Injection

Carboxyphosphonic acid Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Carboxyphosphonic acid Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Carboxyphosphonic acid Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Carboxyphosphonic acid side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Carboxyphosphonic acid Patient Information

Carboxyphosphonic acid Organisms Affected

Human herpes viruses