Carboxyphosphonic acid
Carboxyphosphonic acid Brand names, Carboxyphosphonic acid Analogs
Carboxyphosphonic acid Brand Names Mixture
- No information avaliable
Carboxyphosphonic acid Chemical_Formula
CH3O5P
Carboxyphosphonic acid RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Carboxyphosphonic acid fda sheet
Carboxyphosphonic acid msds (material safety sheet)
Carboxyphosphonic acid Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Carboxyphosphonic acid Molecular Weight
126.005 g/mol
Carboxyphosphonic acid Melting Point
88.06 oC
Carboxyphosphonic acid H2O Solubility
Complete
Carboxyphosphonic acid State
Solid
Carboxyphosphonic acid LogP
No information avaliable
Carboxyphosphonic acid Dosage Forms
Injection
Carboxyphosphonic acid Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Carboxyphosphonic acid Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Carboxyphosphonic acid Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Carboxyphosphonic acid side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Carboxyphosphonic acid Patient Information
Carboxyphosphonic acid Organisms Affected
Human herpes viruses
