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Foscarmet Brand names, Foscarmet Analogs

Foscarmet Brand Names Mixture

  • No information avaliable

Foscarmet Chemical_Formula


Foscarmet RX_link

Foscarmet fda sheet

Foscarmet msds (material safety sheet)

Foscarmet MSDS

Foscarmet Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

Foscarmet Molecular Weight

126.005 g/mol

Foscarmet Melting Point

88.06 oC

Foscarmet H2O Solubility


Foscarmet State


Foscarmet LogP

No information avaliable

Foscarmet Dosage Forms


Foscarmet Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Foscarmet Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Foscarmet Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Foscarmet side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Foscarmet Patient Information

Foscarmet Organisms Affected

Human herpes viruses