Foscarmet
Foscarmet Brand names, Foscarmet Analogs
Foscarmet Brand Names Mixture
- No information avaliable
Foscarmet Chemical_Formula
CH3O5P
Foscarmet RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Foscarmet fda sheet
Foscarmet msds (material safety sheet)
Foscarmet Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Foscarmet Molecular Weight
126.005 g/mol
Foscarmet Melting Point
88.06 oC
Foscarmet H2O Solubility
Complete
Foscarmet State
Solid
Foscarmet LogP
No information avaliable
Foscarmet Dosage Forms
Injection
Foscarmet Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Foscarmet Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Foscarmet Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Foscarmet side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Foscarmet Patient Information
Foscarmet Organisms Affected
Human herpes viruses
