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Foscarnet sodium Brand names, Foscarnet sodium Analogs

Foscarnet sodium Brand Names Mixture

  • No information avaliable

Foscarnet sodium Chemical_Formula


Foscarnet sodium RX_link

Foscarnet sodium fda sheet

Foscarnet sodium msds (material safety sheet)

Foscarnet_sodium MSDS

Foscarnet sodium Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

Foscarnet sodium Molecular Weight

126.005 g/mol

Foscarnet sodium Melting Point

88.06 oC

Foscarnet sodium H2O Solubility


Foscarnet sodium State


Foscarnet sodium LogP

No information avaliable

Foscarnet sodium Dosage Forms


Foscarnet sodium Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Foscarnet sodium Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Foscarnet sodium Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Foscarnet sodium side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Foscarnet sodium Patient Information

Foscarnet sodium Organisms Affected

Human herpes viruses