Foscarnet sodium
Foscarnet sodium Brand names, Foscarnet sodium Analogs
Foscarnet sodium Brand Names Mixture
- No information avaliable
Foscarnet sodium Chemical_Formula
CH3O5P
Foscarnet sodium RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Foscarnet sodium fda sheet
Foscarnet sodium msds (material safety sheet)
Foscarnet sodium Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Foscarnet sodium Molecular Weight
126.005 g/mol
Foscarnet sodium Melting Point
88.06 oC
Foscarnet sodium H2O Solubility
Complete
Foscarnet sodium State
Solid
Foscarnet sodium LogP
No information avaliable
Foscarnet sodium Dosage Forms
Injection
Foscarnet sodium Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Foscarnet sodium Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Foscarnet sodium Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Foscarnet sodium side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Foscarnet sodium Patient Information
Foscarnet sodium Organisms Affected
Human herpes viruses
