Foscavir
Foscavir Brand names, Foscavir Analogs
Foscavir Brand Names Mixture
- No information avaliable
Foscavir Chemical_Formula
CH3O5P
Foscavir RX_link
http://www.rxlist.com/cgi/generic2/foscarnet.htm
Foscavir fda sheet
Foscavir msds (material safety sheet)
Foscavir Synthesis Reference
Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)
Foscavir Molecular Weight
126.005 g/mol
Foscavir Melting Point
88.06 oC
Foscavir H2O Solubility
Complete
Foscavir State
Solid
Foscavir LogP
No information avaliable
Foscavir Dosage Forms
Injection
Foscavir Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Foscavir Pharmacology
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Foscavir Absorption
Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Foscavir side effects and Toxicity
Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.
Foscavir Patient Information
Foscavir Organisms Affected
Human herpes viruses
