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Foscavir Brand names, Foscavir Analogs

Foscavir Brand Names Mixture

  • No information avaliable

Foscavir Chemical_Formula


Foscavir RX_link

Foscavir fda sheet

Foscavir msds (material safety sheet)

Foscavir MSDS

Foscavir Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

Foscavir Molecular Weight

126.005 g/mol

Foscavir Melting Point

88.06 oC

Foscavir H2O Solubility


Foscavir State


Foscavir LogP

No information avaliable

Foscavir Dosage Forms


Foscavir Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Foscavir Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Foscavir Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Foscavir side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Foscavir Patient Information

Foscavir Organisms Affected

Human herpes viruses