Trichloromethiadiazide
Trichloromethiadiazide Brand names, Trichloromethiadiazide Analogs
- Achletin
- Anatran
- Anistadin
- Aponorin
- Carvacron
- Chlopolidine
- Cretonin
- Diu-Hydrin
- Diurazida
- Diurese
- Diuroral
- Esmarin
- Eurinol
- Fluitran
- Flurese
- Flutra
- Gangesol
- Hydrotrichlorothiazide
- Intromene
- Isestran
- Kubacron
- Metahydrin
- Metatensin
- Metatensin #2
- Metatensin #4
- Nakva
- Naqua
- Naquasone
- Naquival
- Salurin
- Schebitran
- Tachionin
- Tolcasone
- Trichlorex
- Trichlormas
- Trichlormetazid
- Trichlormethiazid
- Trichlormethiazide W/ Reserpine
- Trichloromethiadiazide
- Trichloromethiazide
- Triclordiuride
- Triclormetiazide
- Triflumen
Trichloromethiadiazide Brand Names Mixture
- No information avaliable
Trichloromethiadiazide Chemical_Formula
C8H8Cl3N3O4S2
Trichloromethiadiazide RX_link
No information avaliable
Trichloromethiadiazide fda sheet
Trichloromethiadiazide msds (material safety sheet)
Trichloromethiadiazide Synthesis Reference
No information avaliable
Trichloromethiadiazide Molecular Weight
380.657 g/mol
Trichloromethiadiazide Melting Point
No information avaliable
Trichloromethiadiazide H2O Solubility
No information avaliable
Trichloromethiadiazide State
Solid
Trichloromethiadiazide LogP
1.023
Trichloromethiadiazide Dosage Forms
No information avaliable
Trichloromethiadiazide Indication
Used in the treatment of oedema (including that associated with heart failure) and hypertension.
Trichloromethiadiazide Pharmacology
Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Trichloromethiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomer-ulonephritis, and chronic renal failure. Trichloromethiazide is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Like other thiazides, Trichloromethiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Trichloromethiadiazide Absorption
No information avaliable
Trichloromethiadiazide side effects and Toxicity
Oral Rat LD50 = 5600 mg/kg, oral Mouse LD50 = 2600 mg/kg
Trichloromethiadiazide Patient Information
No information avaliable
Trichloromethiadiazide Organisms Affected
Humans and other mammals
