Trichlorex en es it fr

Trichlorex Brand names, Trichlorex Analogs

Trichlorex Brand Names Mixture

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Trichlorex Chemical_Formula


Trichlorex RX_link

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Trichlorex fda sheet

Trichlorex msds (material safety sheet)

Trichlorex MSDS

Trichlorex Synthesis Reference

No information avaliable

Trichlorex Molecular Weight

380.657 g/mol

Trichlorex Melting Point

No information avaliable

Trichlorex H2O Solubility

No information avaliable

Trichlorex State


Trichlorex LogP


Trichlorex Dosage Forms

No information avaliable

Trichlorex Indication

Used in the treatment of oedema (including that associated with heart failure) and hypertension.

Trichlorex Pharmacology

Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Trichloromethiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomer-ulonephritis, and chronic renal failure. Trichloromethiazide is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Like other thiazides, Trichloromethiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Trichlorex Absorption

No information avaliable

Trichlorex side effects and Toxicity

Oral Rat LD50 = 5600 mg/kg, oral Mouse LD50 = 2600 mg/kg

Trichlorex Patient Information

No information avaliable

Trichlorex Organisms Affected

Humans and other mammals