Achletin en es it fr

Achletin Brand names, Achletin Analogs

Achletin Brand Names Mixture

  • No information avaliable

Achletin Chemical_Formula


Achletin RX_link

No information avaliable

Achletin fda sheet

Achletin msds (material safety sheet)

Achletin MSDS

Achletin Synthesis Reference

No information avaliable

Achletin Molecular Weight

380.657 g/mol

Achletin Melting Point

No information avaliable

Achletin H2O Solubility

No information avaliable

Achletin State


Achletin LogP


Achletin Dosage Forms

No information avaliable

Achletin Indication

Used in the treatment of oedema (including that associated with heart failure) and hypertension.

Achletin Pharmacology

Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Trichloromethiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomer-ulonephritis, and chronic renal failure. Trichloromethiazide is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Like other thiazides, Trichloromethiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Achletin Absorption

No information avaliable

Achletin side effects and Toxicity

Oral Rat LD50 = 5600 mg/kg, oral Mouse LD50 = 2600 mg/kg

Achletin Patient Information

No information avaliable

Achletin Organisms Affected

Humans and other mammals