Diuroral
Diuroral Brand names, Diuroral Analogs
- Achletin
- Anatran
- Anistadin
- Aponorin
- Carvacron
- Chlopolidine
- Cretonin
- Diu-Hydrin
- Diurazida
- Diurese
- Diuroral
- Esmarin
- Eurinol
- Fluitran
- Flurese
- Flutra
- Gangesol
- Hydrotrichlorothiazide
- Intromene
- Isestran
- Kubacron
- Metahydrin
- Metatensin
- Metatensin #2
- Metatensin #4
- Nakva
- Naqua
- Naquasone
- Naquival
- Salurin
- Schebitran
- Tachionin
- Tolcasone
- Trichlorex
- Trichlormas
- Trichlormetazid
- Trichlormethiazid
- Trichlormethiazide W/ Reserpine
- Trichloromethiadiazide
- Trichloromethiazide
- Triclordiuride
- Triclormetiazide
- Triflumen
Diuroral Brand Names Mixture
- No information avaliable
Diuroral Chemical_Formula
C8H8Cl3N3O4S2
Diuroral RX_link
No information avaliable
Diuroral fda sheet
Diuroral msds (material safety sheet)
Diuroral Synthesis Reference
No information avaliable
Diuroral Molecular Weight
380.657 g/mol
Diuroral Melting Point
No information avaliable
Diuroral H2O Solubility
No information avaliable
Diuroral State
Solid
Diuroral LogP
1.023
Diuroral Dosage Forms
No information avaliable
Diuroral Indication
Used in the treatment of oedema (including that associated with heart failure) and hypertension.
Diuroral Pharmacology
Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Trichloromethiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomer-ulonephritis, and chronic renal failure. Trichloromethiazide is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Like other thiazides, Trichloromethiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Diuroral Absorption
No information avaliable
Diuroral side effects and Toxicity
Oral Rat LD50 = 5600 mg/kg, oral Mouse LD50 = 2600 mg/kg
Diuroral Patient Information
No information avaliable
Diuroral Organisms Affected
Humans and other mammals
