Quinapril
Quinapril Brand names, Quinapril Analogs
Quinapril Brand Names Mixture
- No information avaliable
Quinapril Chemical_Formula
C25H30N2O5
Quinapril RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Quinapril fda sheet
Quinapril msds (material safety sheet)
Quinapril Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Quinapril Molecular Weight
438.516 g/mol
Quinapril Melting Point
120-130oC
Quinapril H2O Solubility
1 mg/L
Quinapril State
Solid
Quinapril LogP
3.384
Quinapril Dosage Forms
Tablets
Quinapril Indication
For the treatment of hypertension and chronic heart failure.
Quinapril Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Quinapril Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Quinapril side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Quinapril Patient Information
Quinapril Organisms Affected
Humans and other mammals
