Quinapril Hcl
Quinapril Hcl Brand names, Quinapril Hcl Analogs
Quinapril Hcl Brand Names Mixture
- No information avaliable
Quinapril Hcl Chemical_Formula
C25H30N2O5
Quinapril Hcl RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Quinapril Hcl fda sheet
Quinapril Hcl msds (material safety sheet)
Quinapril Hcl Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Quinapril Hcl Molecular Weight
438.516 g/mol
Quinapril Hcl Melting Point
120-130oC
Quinapril Hcl H2O Solubility
1 mg/L
Quinapril Hcl State
Solid
Quinapril Hcl LogP
3.384
Quinapril Hcl Dosage Forms
Tablets
Quinapril Hcl Indication
For the treatment of hypertension and chronic heart failure.
Quinapril Hcl Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Quinapril Hcl Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Quinapril Hcl side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Quinapril Hcl Patient Information
Quinapril Hcl Organisms Affected
Humans and other mammals
