Acequin
Acequin Brand names, Acequin Analogs
Acequin Brand Names Mixture
- No information avaliable
Acequin Chemical_Formula
C25H30N2O5
Acequin RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Acequin fda sheet
Acequin msds (material safety sheet)
Acequin Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Acequin Molecular Weight
438.516 g/mol
Acequin Melting Point
120-130oC
Acequin H2O Solubility
1 mg/L
Acequin State
Solid
Acequin LogP
3.384
Acequin Dosage Forms
Tablets
Acequin Indication
For the treatment of hypertension and chronic heart failure.
Acequin Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Acequin Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Acequin side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Acequin Patient Information
Acequin Organisms Affected
Humans and other mammals
