Accupril
Accupril Brand names, Accupril Analogs
Accupril Brand Names Mixture
- No information avaliable
Accupril Chemical_Formula
C25H30N2O5
Accupril RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Accupril fda sheet
Accupril msds (material safety sheet)
Accupril Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Accupril Molecular Weight
438.516 g/mol
Accupril Melting Point
120-130oC
Accupril H2O Solubility
1 mg/L
Accupril State
Solid
Accupril LogP
3.384
Accupril Dosage Forms
Tablets
Accupril Indication
For the treatment of hypertension and chronic heart failure.
Accupril Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Accupril Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Accupril side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Accupril Patient Information
Accupril Organisms Affected
Humans and other mammals
