Korec
Korec Brand names, Korec Analogs
Korec Brand Names Mixture
- No information avaliable
Korec Chemical_Formula
C25H30N2O5
Korec RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Korec fda sheet
Korec msds (material safety sheet)
Korec Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Korec Molecular Weight
438.516 g/mol
Korec Melting Point
120-130oC
Korec H2O Solubility
1 mg/L
Korec State
Solid
Korec LogP
3.384
Korec Dosage Forms
Tablets
Korec Indication
For the treatment of hypertension and chronic heart failure.
Korec Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Korec Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Korec side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Korec Patient Information
Korec Organisms Affected
Humans and other mammals
