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Accuprin Brand names, Accuprin Analogs

Accuprin Brand Names Mixture

  • No information avaliable

Accuprin Chemical_Formula


Accuprin RX_link

Accuprin fda sheet

Accuprin msds (material safety sheet)

Accuprin Synthesis Reference

M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)

Accuprin Molecular Weight

438.516 g/mol

Accuprin Melting Point


Accuprin H2O Solubility

1 mg/L

Accuprin State


Accuprin LogP


Accuprin Dosage Forms


Accuprin Indication

For the treatment of hypertension and chronic heart failure.

Accuprin Pharmacology

Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.

Accuprin Absorption

Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.

Accuprin side effects and Toxicity

Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).

Accuprin Patient Information

Accuprin Organisms Affected

Humans and other mammals