Accupro
Accupro Brand names, Accupro Analogs
Accupro Brand Names Mixture
- No information avaliable
Accupro Chemical_Formula
C25H30N2O5
Accupro RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Accupro fda sheet
Accupro msds (material safety sheet)
Accupro Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Accupro Molecular Weight
438.516 g/mol
Accupro Melting Point
120-130oC
Accupro H2O Solubility
1 mg/L
Accupro State
Solid
Accupro LogP
3.384
Accupro Dosage Forms
Tablets
Accupro Indication
For the treatment of hypertension and chronic heart failure.
Accupro Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Accupro Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Accupro side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Accupro Patient Information
Accupro Organisms Affected
Humans and other mammals
