Quinapril Hydrochloride
Quinapril Hydrochloride Brand names, Quinapril Hydrochloride Analogs
Quinapril Hydrochloride Brand Names Mixture
- No information avaliable
Quinapril Hydrochloride Chemical_Formula
C25H30N2O5
Quinapril Hydrochloride RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Quinapril Hydrochloride fda sheet
Quinapril Hydrochloride msds (material safety sheet)
Quinapril Hydrochloride Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Quinapril Hydrochloride Molecular Weight
438.516 g/mol
Quinapril Hydrochloride Melting Point
120-130oC
Quinapril Hydrochloride H2O Solubility
1 mg/L
Quinapril Hydrochloride State
Solid
Quinapril Hydrochloride LogP
3.384
Quinapril Hydrochloride Dosage Forms
Tablets
Quinapril Hydrochloride Indication
For the treatment of hypertension and chronic heart failure.
Quinapril Hydrochloride Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Quinapril Hydrochloride Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Quinapril Hydrochloride side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Quinapril Hydrochloride Patient Information
Quinapril Hydrochloride Organisms Affected
Humans and other mammals
