Pimecrolimus
Brand names,
Pimecrolimus
Analogs
Pimecrolimus
Brand Names Mixture
Pimecrolimus
Chemical_Formula
C43H68ClNO11
Pimecrolimus
RX_link
http://www.rxlist.com/cgi/generic/elidel.htm
Pimecrolimus
fda sheet
Pimecrolimus
msds (material safety sheet)
Pimecrolimus
Synthesis Reference
No information avaliable
Pimecrolimus
Molecular Weight
810.453 g/mol
Pimecrolimus
Melting Point
No information avaliable
Pimecrolimus
H2O Solubility
No information avaliable
Pimecrolimus
State
Solid
Pimecrolimus
LogP
5.099
Pimecrolimus
Dosage Forms
Cream
Pimecrolimus
Indication
For treatment of mild to moderate atopic dermatitis.
Pimecrolimus
Pharmacology
Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema). Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers. Scientists do not know exactly how pimecrolimus reduces the manifestations of atopic dermatitis, but pimecrolimus reduces the action of T-cells and mast cells which are part of the immune system and contribute to responses of the immune system. Pimecrolimus prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulate T-cells. Pimecrolimus also reduces the ability of mast cells to release chemicals that promote inflammation.
Pimecrolimus
Absorption
Because of the low systemic absorption of pimecrolimus following topical application the calculation of standard pharmacokinetic measures such as AUC, Cmax, half-life, etc. cannot be reliably done.
Pimecrolimus
side effects and Toxicity
Side effects include burning sensation, irritation, pruritus, erythema, and skin infections, at the application site.
Pimecrolimus
Patient Information
Pimecrolimus
Organisms Affected
Humans and other mammals