Sal amarum
Brand names,
Sal amarum
Analogs
Sal amarum
Brand Names Mixture
Sal amarum
Chemical_Formula
C43H68ClNO11
Sal amarum
RX_link
http://www.rxlist.com/cgi/generic/elidel.htm
Sal amarum
fda sheet
Sal amarum
msds (material safety sheet)
Sal amarum
Synthesis Reference
No information avaliable
Sal amarum
Molecular Weight
810.453 g/mol
Sal amarum
Melting Point
No information avaliable
Sal amarum
H2O Solubility
No information avaliable
Sal amarum
State
Solid
Sal amarum
LogP
5.099
Sal amarum
Dosage Forms
Cream
Sal amarum
Indication
For treatment of mild to moderate atopic dermatitis.
Sal amarum
Pharmacology
Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema). Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers. Scientists do not know exactly how pimecrolimus reduces the manifestations of atopic dermatitis, but pimecrolimus reduces the action of T-cells and mast cells which are part of the immune system and contribute to responses of the immune system. Pimecrolimus prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulate T-cells. Pimecrolimus also reduces the ability of mast cells to release chemicals that promote inflammation.
Sal amarum
Absorption
Because of the low systemic absorption of pimecrolimus following topical application the calculation of standard pharmacokinetic measures such as AUC, Cmax, half-life, etc. cannot be reliably done.
Sal amarum
side effects and Toxicity
Side effects include burning sensation, irritation, pruritus, erythema, and skin infections, at the application site.
Sal amarum
Patient Information
Sal amarum
Organisms Affected
Humans and other mammals