Salts of England
Brand names,
Salts of England
Analogs
Salts of England
Brand Names Mixture
Salts of England
Chemical_Formula
C43H68ClNO11
Salts of England
RX_link
http://www.rxlist.com/cgi/generic/elidel.htm
Salts of England
fda sheet
Salts of England
msds (material safety sheet)
Salts of England
Synthesis Reference
No information avaliable
Salts of England
Molecular Weight
810.453 g/mol
Salts of England
Melting Point
No information avaliable
Salts of England
H2O Solubility
No information avaliable
Salts of England
State
Solid
Salts of England
LogP
5.099
Salts of England
Dosage Forms
Cream
Salts of England
Indication
For treatment of mild to moderate atopic dermatitis.
Salts of England
Pharmacology
Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema). Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers. Scientists do not know exactly how pimecrolimus reduces the manifestations of atopic dermatitis, but pimecrolimus reduces the action of T-cells and mast cells which are part of the immune system and contribute to responses of the immune system. Pimecrolimus prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulate T-cells. Pimecrolimus also reduces the ability of mast cells to release chemicals that promote inflammation.
Salts of England
Absorption
Because of the low systemic absorption of pimecrolimus following topical application the calculation of standard pharmacokinetic measures such as AUC, Cmax, half-life, etc. cannot be reliably done.
Salts of England
side effects and Toxicity
Side effects include burning sensation, irritation, pruritus, erythema, and skin infections, at the application site.
Salts of England
Patient Information
Salts of England
Organisms Affected
Humans and other mammals