MgSO4
Brand names,
MgSO4
Analogs
MgSO4
Brand Names Mixture
MgSO4
Chemical_Formula
C43H68ClNO11
MgSO4
RX_link
http://www.rxlist.com/cgi/generic/elidel.htm
MgSO4
fda sheet
MgSO4
msds (material safety sheet)
MgSO4
Synthesis Reference
No information avaliable
MgSO4
Molecular Weight
810.453 g/mol
MgSO4
Melting Point
No information avaliable
MgSO4
H2O Solubility
No information avaliable
MgSO4
State
Solid
MgSO4
LogP
5.099
MgSO4
Dosage Forms
Cream
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Indication
For treatment of mild to moderate atopic dermatitis.
MgSO4
Pharmacology
Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema). Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers. Scientists do not know exactly how pimecrolimus reduces the manifestations of atopic dermatitis, but pimecrolimus reduces the action of T-cells and mast cells which are part of the immune system and contribute to responses of the immune system. Pimecrolimus prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulate T-cells. Pimecrolimus also reduces the ability of mast cells to release chemicals that promote inflammation.
MgSO4
Absorption
Because of the low systemic absorption of pimecrolimus following topical application the calculation of standard pharmacokinetic measures such as AUC, Cmax, half-life, etc. cannot be reliably done.
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side effects and Toxicity
Side effects include burning sensation, irritation, pruritus, erythema, and skin infections, at the application site.
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Patient Information
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Organisms Affected
Humans and other mammals