Ovarid
Ovarid Brand names, Ovarid Analogs
Ovarid Brand Names Mixture
- No information avaliable
Ovarid Chemical_Formula
C7H7NO3
Ovarid RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Ovarid fda sheet
Ovarid msds (material safety sheet)
Ovarid Synthesis Reference
No information avaliable
Ovarid Molecular Weight
153.135 g/mol
Ovarid Melting Point
283 oC
Ovarid H2O Solubility
0.84 g/L at 20°C
Ovarid State
Solid
Ovarid LogP
1.012
Ovarid Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Ovarid Indication
For the treatment of active ulcerative proctitis.
Ovarid Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Ovarid Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Ovarid side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Ovarid Patient Information
Ovarid Organisms Affected
Humans and other mammals
