Megace
Megace Brand names, Megace Analogs
Megace Brand Names Mixture
- No information avaliable
Megace Chemical_Formula
C7H7NO3
Megace RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Megace fda sheet
Megace msds (material safety sheet)
Megace Synthesis Reference
No information avaliable
Megace Molecular Weight
153.135 g/mol
Megace Melting Point
283 oC
Megace H2O Solubility
0.84 g/L at 20°C
Megace State
Solid
Megace LogP
1.012
Megace Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Megace Indication
For the treatment of active ulcerative proctitis.
Megace Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Megace Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Megace side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Megace Patient Information
Megace Organisms Affected
Humans and other mammals
