Megestrol Acetate
Megestrol Acetate Brand names, Megestrol Acetate Analogs
Megestrol Acetate Brand Names Mixture
- No information avaliable
Megestrol Acetate Chemical_Formula
C7H7NO3
Megestrol Acetate RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Megestrol Acetate fda sheet
Megestrol Acetate msds (material safety sheet)
Megestrol Acetate Synthesis Reference
No information avaliable
Megestrol Acetate Molecular Weight
153.135 g/mol
Megestrol Acetate Melting Point
283 oC
Megestrol Acetate H2O Solubility
0.84 g/L at 20°C
Megestrol Acetate State
Solid
Megestrol Acetate LogP
1.012
Megestrol Acetate Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Megestrol Acetate Indication
For the treatment of active ulcerative proctitis.
Megestrol Acetate Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Megestrol Acetate Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Megestrol Acetate side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Megestrol Acetate Patient Information
Megestrol Acetate Organisms Affected
Humans and other mammals
