Megestil
Megestil Brand names, Megestil Analogs
Megestil Brand Names Mixture
- No information avaliable
Megestil Chemical_Formula
C7H7NO3
Megestil RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Megestil fda sheet
Megestil msds (material safety sheet)
Megestil Synthesis Reference
No information avaliable
Megestil Molecular Weight
153.135 g/mol
Megestil Melting Point
283 oC
Megestil H2O Solubility
0.84 g/L at 20°C
Megestil State
Solid
Megestil LogP
1.012
Megestil Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Megestil Indication
For the treatment of active ulcerative proctitis.
Megestil Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Megestil Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Megestil side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Megestil Patient Information
Megestil Organisms Affected
Humans and other mammals
