Megestryl acetate
Megestryl acetate Brand names, Megestryl acetate Analogs
Megestryl acetate Brand Names Mixture
- No information avaliable
Megestryl acetate Chemical_Formula
C7H7NO3
Megestryl acetate RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Megestryl acetate fda sheet
Megestryl acetate msds (material safety sheet)
Megestryl acetate Synthesis Reference
No information avaliable
Megestryl acetate Molecular Weight
153.135 g/mol
Megestryl acetate Melting Point
283 oC
Megestryl acetate H2O Solubility
0.84 g/L at 20°C
Megestryl acetate State
Solid
Megestryl acetate LogP
1.012
Megestryl acetate Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Megestryl acetate Indication
For the treatment of active ulcerative proctitis.
Megestryl acetate Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Megestryl acetate Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Megestryl acetate side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Megestryl acetate Patient Information
Megestryl acetate Organisms Affected
Humans and other mammals
