Megestin
Megestin Brand names, Megestin Analogs
Megestin Brand Names Mixture
- No information avaliable
Megestin Chemical_Formula
C7H7NO3
Megestin RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Megestin fda sheet
Megestin msds (material safety sheet)
Megestin Synthesis Reference
No information avaliable
Megestin Molecular Weight
153.135 g/mol
Megestin Melting Point
283 oC
Megestin H2O Solubility
0.84 g/L at 20°C
Megestin State
Solid
Megestin LogP
1.012
Megestin Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Megestin Indication
For the treatment of active ulcerative proctitis.
Megestin Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Megestin Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Megestin side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Megestin Patient Information
Megestin Organisms Affected
Humans and other mammals
