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DMAP Brand names, DMAP Analogs

DMAP Brand Names Mixture

  • No information avaliable

DMAP Chemical_Formula


DMAP RX_link

DMAP fda sheet


DMAP msds (material safety sheet)


DMAP Synthesis Reference

No information avaliable

DMAP Molecular Weight

153.135 g/mol

DMAP Melting Point

283 oC

DMAP H2O Solubility

0.84 g/L at 20°C

DMAP State




DMAP Dosage Forms

Rectal suppository (500 mg or 1000 mg)

DMAP Indication

For the treatment of active ulcerative proctitis.

DMAP Pharmacology

Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.

DMAP Absorption

20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.

DMAP side effects and Toxicity

Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.

DMAP Patient Information

DMAP Organisms Affected

Humans and other mammals