DMAP
DMAP Brand names, DMAP Analogs
DMAP Brand Names Mixture
- No information avaliable
DMAP Chemical_Formula
C7H7NO3
DMAP RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
DMAP fda sheet
DMAP msds (material safety sheet)
DMAP Synthesis Reference
No information avaliable
DMAP Molecular Weight
153.135 g/mol
DMAP Melting Point
283 oC
DMAP H2O Solubility
0.84 g/L at 20°C
DMAP State
Solid
DMAP LogP
1.012
DMAP Dosage Forms
Rectal suppository (500 mg or 1000 mg)
DMAP Indication
For the treatment of active ulcerative proctitis.
DMAP Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
DMAP Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
DMAP side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
DMAP Patient Information
DMAP Organisms Affected
Humans and other mammals
