Magestin
Magestin Brand names, Magestin Analogs
Magestin Brand Names Mixture
- No information avaliable
Magestin Chemical_Formula
C7H7NO3
Magestin RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Magestin fda sheet
Magestin msds (material safety sheet)
Magestin Synthesis Reference
No information avaliable
Magestin Molecular Weight
153.135 g/mol
Magestin Melting Point
283 oC
Magestin H2O Solubility
0.84 g/L at 20°C
Magestin State
Solid
Magestin LogP
1.012
Magestin Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Magestin Indication
For the treatment of active ulcerative proctitis.
Magestin Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Magestin Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Magestin side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Magestin Patient Information
Magestin Organisms Affected
Humans and other mammals
