Maygace
Maygace Brand names, Maygace Analogs
Maygace Brand Names Mixture
- No information avaliable
Maygace Chemical_Formula
C7H7NO3
Maygace RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Maygace fda sheet
Maygace msds (material safety sheet)
Maygace Synthesis Reference
No information avaliable
Maygace Molecular Weight
153.135 g/mol
Maygace Melting Point
283 oC
Maygace H2O Solubility
0.84 g/L at 20°C
Maygace State
Solid
Maygace LogP
1.012
Maygace Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Maygace Indication
For the treatment of active ulcerative proctitis.
Maygace Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Maygace Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Maygace side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Maygace Patient Information
Maygace Organisms Affected
Humans and other mammals
