MGA
MGA Brand names, MGA Analogs
MGA Brand Names Mixture
- No information avaliable
MGA Chemical_Formula
C7H7NO3
MGA RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
MGA fda sheet
MGA msds (material safety sheet)
MGA Synthesis Reference
No information avaliable
MGA Molecular Weight
153.135 g/mol
MGA Melting Point
283 oC
MGA H2O Solubility
0.84 g/L at 20°C
MGA State
Solid
MGA LogP
1.012
MGA Dosage Forms
Rectal suppository (500 mg or 1000 mg)
MGA Indication
For the treatment of active ulcerative proctitis.
MGA Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
MGA Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
MGA side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
MGA Patient Information
MGA Organisms Affected
Humans and other mammals
