Nitrendipine
Nitrendipine Brand names, Nitrendipine Analogs
Nitrendipine Brand Names Mixture
- No information avaliable
Nitrendipine Chemical_Formula
C18H20N2O6
Nitrendipine RX_link
No information avaliable
Nitrendipine fda sheet
Nitrendipine msds (material safety sheet)
Nitrendipine Synthesis Reference
H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934
Nitrendipine Molecular Weight
360.361 g/mol
Nitrendipine Melting Point
156-160 oC
Nitrendipine H2O Solubility
Insoluble
Nitrendipine State
Solid
Nitrendipine LogP
2.756
Nitrendipine Dosage Forms
No information avaliable
Nitrendipine Indication
For the treatment of mild to moderate hypertension
Nitrendipine Pharmacology
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Nitrendipine Absorption
No information avaliable
Nitrendipine side effects and Toxicity
No information avaliable
Nitrendipine Patient Information
No information avaliable
Nitrendipine Organisms Affected
Humans and other mammals
