Nitrepin
Nitrepin Brand names, Nitrepin Analogs
Nitrepin Brand Names Mixture
- No information avaliable
Nitrepin Chemical_Formula
C18H20N2O6
Nitrepin RX_link
No information avaliable
Nitrepin fda sheet
Nitrepin msds (material safety sheet)
Nitrepin Synthesis Reference
H. Meyar et al., Ger. pat 2117571; eidem, US pat. 3799934
Nitrepin Molecular Weight
360.361 g/mol
Nitrepin Melting Point
156-160 oC
Nitrepin H2O Solubility
Insoluble
Nitrepin State
Solid
Nitrepin LogP
2.756
Nitrepin Dosage Forms
No information avaliable
Nitrepin Indication
For the treatment of mild to moderate hypertension
Nitrepin Pharmacology
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Nitrepin Absorption
No information avaliable
Nitrepin side effects and Toxicity
No information avaliable
Nitrepin Patient Information
No information avaliable
Nitrepin Organisms Affected
Humans and other mammals
